This experiment was conducted to evaluate the efficacy of saponin extract, algae Chlorella vulgaris and a bio-nematicide BioNematon (a commercial formulation of the Paecilomyces lilacinus, half dose) and its possibility of creating an integrated control program on root-knot nematodes infected cowpea under open field conditions compared with a chemical nematicide Carbofuran, as well as the effect of these treatments on the vegetative characteristics of cowpea plants under study. All treatments caused reduction percentage in root-knot nematode Meloidogyne incognita juveniles, to take into the triple treatment (saponins extract + algae + BioNematon half dose) which gave the highest reduction percentage (82.6%), followed by the chemical nematicide Carbofuran (80.3%), then the BioNematon half dose, algae and saponins extract solely by achievement (67.3, 66.3 and 58.4%), respectively, compared with control. Tri treatment (saponins extract + algae + BioNematon half dose) caused obviousness decrement in mature females, egg masses and root galls (82.9, 85.8, 80%), than that found by application of Carbofuran (81.1, 82.8 and 80.0%), respectively. As well as triple treatment also improved the vegetative characteristics of cowpea plants, it caused an increase in plant height, shoot weight and root weight by percentages (75.3, 78.8 and 96.3%) while contrariwise occurred by appliance of Carbofuran (46.9, 38.7 and 83.7%), respectively, compared to the control.