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amar, I., eissa, R., said, S., gabar, M. (2024). DINOTEFURAN INSECTICIDE EVOKES DISRUPTING OESTROUS CYCLE IN RAT FEMALE: THE AMELIORATIVE ROLE OF ROSEMARY EXTRACT. Menoufia Journal of Plant Protection, 9(8), 241-252. doi: 10.21608/mjapam.2024.267101.1031
ibrahim amar; ragaa eissa; samah said; marwa gabar. "DINOTEFURAN INSECTICIDE EVOKES DISRUPTING OESTROUS CYCLE IN RAT FEMALE: THE AMELIORATIVE ROLE OF ROSEMARY EXTRACT". Menoufia Journal of Plant Protection, 9, 8, 2024, 241-252. doi: 10.21608/mjapam.2024.267101.1031
amar, I., eissa, R., said, S., gabar, M. (2024). 'DINOTEFURAN INSECTICIDE EVOKES DISRUPTING OESTROUS CYCLE IN RAT FEMALE: THE AMELIORATIVE ROLE OF ROSEMARY EXTRACT', Menoufia Journal of Plant Protection, 9(8), pp. 241-252. doi: 10.21608/mjapam.2024.267101.1031
amar, I., eissa, R., said, S., gabar, M. DINOTEFURAN INSECTICIDE EVOKES DISRUPTING OESTROUS CYCLE IN RAT FEMALE: THE AMELIORATIVE ROLE OF ROSEMARY EXTRACT. Menoufia Journal of Plant Protection, 2024; 9(8): 241-252. doi: 10.21608/mjapam.2024.267101.1031

DINOTEFURAN INSECTICIDE EVOKES DISRUPTING OESTROUS CYCLE IN RAT FEMALE: THE AMELIORATIVE ROLE OF ROSEMARY EXTRACT

Article 8, Volume 9, Issue 8, August 2024, Page 241-252  XML PDF (1.08 MB)
Document Type: Original Article
DOI: 10.21608/mjapam.2024.267101.1031
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Authors
ibrahim amar1; ragaa eissa1; samah said2; marwa gabar email 1
1قسم المبيدات كلية الزراعة جامعة المنوفية
2قسم مبيدات الافات كلية الزراعة جامعة المنوفية
Abstract
Dinotefuran (DINO) is a third-generation neonicotinoid insecticide with extensive worldwide application, resulting in continued human exposure. The present study explored the reproductive toxicity of DINO on oestrous cycle stages in rat females and the ameliorative role of rosemary leaf extract (RE). Twenty rat females were exposed to DINO, RE, and their combination at 73.5 and 230 mg/kg for 14 days. The levels of estrogen and progesterone were measured, and the dysregulation of oestrous cycle stages was monitored. The exposure to DINO resulted in an imbalance in estrogen and progesterone levels. Also, the regulation of oestrous cycle stages was disrupted. These effects were mitigated when rats were administered RE. Altogether, these findings provide insights into the reproductive toxicity of DINO on rat females and the ameliorative effects of RE on DINO-induced toxicity.
Keywords
Dinotefuran; rosemary leaf extract; reproductive toxicity; pesticides
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